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Systems biomedical analysis of Schistosoma japonicum

Ze-Guang HAN MD,

Frontiers of Medicine 2010, Volume 4, Issue 2, Pages 157-165 doi: 10.1007/s11684-010-0034-5

Abstract: Human schistosomiasis, caused mainly by three principal species including , , and , remains a major public health concern worldwide. is prevalent in southern China, being a major disease risk for 66 million people. The blood fluke has a complex life cycle for survival: as a free-living form in fresh water and as a parasite in the snail intermediate and vertebrate definitive hosts. Systems-based biomedical analyses, including genomic, transcriptomic, proteomic and metabonomic approaches, have been performed on the schistosome. These comprehensive investigations have not only characterized the genomic features but also chartered gene and protein expression profiles across genders and developmental stages. The integration of the huge information will lay a global and solid foundation for the molecular architecture of the biology, pathogenesis, and host-parasite interactions of the human blood fluke, which will facilitate the development of a new antischistosomal vaccine and drugs as well as diagnostic markers for the treatment and control of schistosomiasis.

Keywords： Schistosoma japonicum systems biomedical analysis

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A new strategy to control transmission of Schistosoma japonicum

Wang Longde,Zhou Xiaonong,Chen Honggen,Guo Jiagang,Zeng Xiaojun,Hong Xianlin,Xiong Jijie,Wu Xiaohua,Wang Liying,Xia Gang,Hao Yang

Strategic Study of CAE 2009, Volume 11, Issue 5, Pages 37-43

Abstract: strategy for the national program on schistosomiasis control with emphasis on eliminating transmission of Schistosomajaponicum in marsh and lake region, since it is of difficulty to control the transmission of S. japonicumDuring the intervention period,changes were observed in S. japonicum infection in humans, measured theConclusions: A comprehensive control strategy based on interventions to reduce the rate of transmission of S. japonicum

Keywords： schistosomiasis integrated control infectious agent pilot study